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Ting Shi

Research Associate Professor / Associate Researcher

  • Tel: +86-021-34207347
  • Email: tshi@sjtu.edu.cn
  • Address: 800 Dongchuan Road, Shanghai

Education and Research Experience

2007.07-2010.07 Postdoctoral, Chinese Academy of Sciences Shanghai Institute of Materia Medica

2010.07-2013.07 Assistant Researcher, School of Medicine, Shanghai Jiao Tong University.

2013.07- Associate Researcher, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University

Research Interests

Mechanism of Enzyme

Study on the Mechanism of Enzymes

Rational Design of Enzyme

Study on the Rational Design of Enzymes

Bioinformatics

Bioinformatics 

Optimization of Molecules

Optimization of Molecules with QM and QM/MM

Selected Publications

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    Theoretical Studies on the Catalytic Mechanism and Substrate Diversity for Macrocyclization of Pikromycin Thioesterase

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    Theoretical Investigation of the Structural Characteristics in the Active State of Akt1 Kinase

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    Insight into Structural Characteristics of Protein-Substrate Interaction in Pimaricin Thioesterase

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    Hybrubins: Bipyrrole Tetramic Acids Obtained by Crosstalk between a Truncated Undecylprodigiosin Pathway and Heterologous Tetramic Acid Biosynthetic Genes

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    Features of S-nitrosylation based on statistical analysis and molecular dynamics simulation: cysteine acidity, surrounding basicity, steric hindrance and local flexibility

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    Engineering of lysine cyclodeaminase conformational dynamics for relieving substrate and product inhibitions in the biosynthesis of L-pipecolic acid

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    DNA gated photochromism and fluorescent switch in a thiazole orange modified diarylethene

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    Exploring the Desumoylation Process of SENP1: A Study Combined MD Simulations with QM/MM Calculations on SENP1-SUMO1-RanGAP1

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    Structural basis for the transcriptional repressor NicR2 in nicotine degradation from Pseudomonas

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    Theoretical Studies on the Mechanism, Enantioselectivity, and Axial Ligand Effect of a Ru(salen)-Catalyzed Asymmetric Cyclopropanation Reaction